Integration of nanotechnologies in microscale invasive in vivo brain devices

L'abstract è presente nell'allegato / the abstract is in the attachmen

Video summarization by group scoring

In this paper a new model for user-centered video summarization is presented. Involvement of more than one expert in generating the final video summary should be regarded as the main use case for this algorithm. This approach consists of three major steps. First, the video frames are scored by a group of operators. Next, these assigned scores are averaged to produce a singular value for each frame and lastly, the highest scored video frames alongside the corresponding audio and textual contents are extracted to be inserted into the summary. The effectiveness of this approach has been evaluated by comparing the video summaries generated by this system against the results from a number of automatic summarization tools that use different modalities for abstraction

Scalable nanophotonic neural probes for multicolor and on-demand light delivery in brain tissue

Neural probes are in vivo brain-invasive devices that record and manipulate neural circuits using electricity, light, or drugs. The capability to shine distinct wavelengths and control their respective output locations for activation or deactivation of specific groups of neurons is desirable but remains unachieved. Here, we discuss our probe's capability to deliver two independently controllable wavelengths (450 and 655 nm) in the location(s) of interest using nanophotonic directional couplers and ring resonators. These nanophotonics are scalable to dozens of outputs without significantly increasing the device's lateral dimensions. Furthermore, they are entirely passive and thus do not require electrical input that results in heat generation. Besides, we integrate a high number of electrodes for a simultaneous neural activity readout. Thus, we overcome the challenges associated with multicolor illumination for neural devices by exploiting the capability of miniaturizable, passive probes to deliver two different frequencies in several areas of interest. These devices open the path towards investigating the in vivo electrical signal propagation under the individual or simultaneous activation or inhibition of distinct brain regions

Small footprint optoelectrodes using ring resonators for passive light localization.

The combination of electrophysiology and optogenetics enables the exploration of how the brain operates down to a single neuron and its network activity. Neural probes are in vivo invasive devices that integrate sensors and stimulation sites to record and manipulate neuronal activity with high spatiotemporal resolution. State-of-the-art probes are limited by tradeoffs involving their lateral dimension, number of sensors, and ability to access independent stimulation sites. Here, we realize a highly scalable probe that features three-dimensional integration of small-footprint arrays of sensors and nanophotonic circuits to scale the density of sensors per cross-section by one order of magnitude with respect to state-of-the-art devices. For the first time, we overcome the spatial limit of the nanophotonic circuit by coupling only one waveguide to numerous optical ring resonators as passive nanophotonic switches. With this strategy, we achieve accurate on-demand light localization while avoiding spatially demanding bundles of waveguides and demonstrate the feasibility with a proof-of-concept device and its scalability towards high-resolution and low-damage neural optoelectrodes